DISCLAIMER: THIS IS NOT MEDICAL ADVICE! We do not employ doctors or licensed medical professionals, so we do not provide medical advice. Nothing presented here is a substitute for the advice of a DOCTOR or other licensed health care provider. Never stop, start or add medications or supplements to your health or mental health care regime without first checking for interactions or other problems, and thoroughly researching the substance. Before you employ any information here, consult your health care professional. No information here is the result of valid clinical trials.

Dangers of not tapering slowly

 

The Dangers of Cold Turkey, Rapid Discontinuation,
Alternating Days, Bridging and Protracted Acute
Withdrawal Syndrome (PAWS)

 

CYMBALTA HURTS WORSE is a group of peers/patients offering tapering advice that can minimize symptoms and prevent others from suffering.

 

We have been through horrendous Cymbalta withdrawal from decreasing too rapidly, very often at the recommendation of doctors.

 

CHW's Tapering Protocols and Philosophies:

CYMBALTA HURTS WORSE follows research from antidepressant experts Ann Blake-Tracy, Dr. Kelly Brogan and Dr. Peter Breggin.

They have been researching serotonin-affecting drugs, and helping people safely taper off them for
decades. Please Google Ann Blake-Tracy's website, International Coalition for Drug Awareness
(ICDA) and look up the article "Warning on Drug Discontinuation".

CHW advocates for a slow, deliberate taper with decreases of 5% or less, holding 14 days or longer between each decrease.

Antidepressant expert, Ann Blake-Tracy recommends decreases no greater than 5%, and many people find decreases of 5% or 2.5% holding 14 days or longer help them remain most functional for work and family duties. This slow method of tapering can greatly minimize withdrawal and reduce the risk of developing PAWS. Even people who have been on the drug a short time or at a low dose can experience the same bad, long-lasting withdrawal. However, those who have been on the drug for years are at greatest risk of developing PAWS from too rapid a taper.


Safe Tapering vs. Unsafe Discontinuation:

SAFE TAPERING:

Decreases of 5% or less (of previous dose), holding 14 days or more between each decrease. 5% reductions or less are highly recommended.

UNSAFE DISCONTINUATION:

  • Be aware that many doctors will recommend these methods of discontinuation.
  • Going cold turkey (CT), making large and/or rapid decreases, alternating days, bridging to other drugs, using large beads, dumping random numbers of beads or guesstimating, or any other form of "off roading".

The Odds Aren't Good

Research shows that more than 44% to 78% of people following an unsafe method of discontinuation will experience significant withdrawal symptoms.

These will not resolve within 2-3 weeks. 25% will experience difficult, long-lasting withdrawal symptoms and 10% will experience the most severe withdrawals. We cannot predict when they will kick in, how long they will last, who will be hit the hardest, or how each individual will be affected. PAWS can be debilitating, even life-threatening and last months or even years.

QuarterWatch Report on Cymbalta Withdrawal:


Reinstating

After a rapid decrease there is a 2, possibly 3-week window where reinstatement of the drug can reverse the symptoms and head off PAWS.

CHW suggests reinstatement within this window, but only if no other drugs have been introduced, and if the person has not alternated days more than 3 weeks. Once someone has reinstated, they will need to FULLY stabilize before beginning a slow taper as outlined in our files.


When Does PAWS Occur?

Once the reinstatement window has passed (and there is no clear point where that happens), the nervous system may become so destabilized that nothing can reverse or ease the symptoms.

Only time and patience will gradually heal protracted withdrawal. It can last months, or even longer than a year, and be quite debilitating, or even life-threatening. Withdrawal mimics many serious health and mental health disorders. As the medical community does not recognize withdrawal that lasts more than 2 -3 weeks, a person is at risk of having their withdrawal symptoms misdiagnosed as bipolar or other serious health or mental health disorders, and having more drugs applied.


Withdrawal Can Be Delayed

Delayed withdrawal is something else that can hit you after cold turkey or rapid discontinuation.

This usually happens between 2-6 months but can occur before or after that time frame. Just like "the calm before the storm", many people report feeling better for a while only to be hit by harsh withdrawal months later when it is too late to reinstate. It can also be a period of manic behaviour.

If an antidepressant is not tapered slowly, while fortifying the body with healthy nutrition and with supplements, it can produce a wide range of problems:

  • Violent outbursts or actual rage
  • Bouts of overwhelming depression and anxiety
  • A MUCH longer withdrawal and recovery period than if the drug was slowly tapered
  • Overwhelming fatigue that interferes with daily function and work
  • Insomnia, possibly leading to a psychotic break and commitment to a psych ward
  • (Mis)diagnosis of Bipolar, Schizophrenia or other serious mental health conditions
  • Going back on the drugs and having more drugs added
  • Seizures or other life-threatening reactions
  • REM Sleep behavior Disorder which has caused suicide and homicide during a sleep state.

Akathisia

A dangerous condition related to antidepressant use and withdrawal is tardives akathisia.


Rapid Discontinuation, Going "Cold Turkey," and "Off-Roading"

The temptation to get off Cymbalta quickly by rushing the process or trying one's own method of removing or dumping beads out generally ends badly.

The method CHW recommends has been used by thousands of people to get off Cymbalta/Duloxetine with the least amount of ill-effects and discomfort. If you are thinking of going "cold turkey", rushing or "off-roading", please watch this 5 minute video:

The manufacturer of Cymbalta, Eli Lilly's own Med. Guide discusses Discontinuation Syndrome and warns not to stop abruptly. Even the warning labels on the drugs advise that large, abrupt decreases are dangerous.

Look at #6 in this PDF: 

Eli Lily was sued for failing to warn patients and doctors just how dangerous and difficult it is to discontinue Cymbalta/Duloxetine

Articles to Print Off and Give Your Doctor 


Cymbalta's Half-Life and Alternating Days

Cymbalta has a short half-life of 12 hours, which means 12 hours after a dose is taken, the levels of the drug drop to 1/2, and by 24 hours the body will start to go into withdrawal. Alternating days causes the body to go into withdrawal every other day. One day plummeting the dose, the next day skyrocketing it. Every-other-day discontinuation is dangerous and not recommended.


Switching to Other Drugs

BRIDGING to other drugs interferes with the ability to reinstate Cymbalta and then slowly taper off.

It does not necessarily stop antidepressant withdrawal and can leave you with Cymbalta withdrawals as well as another drug to slowly taper off later. CHW does not recommend bridging in an attempt to get through the withdrawal process faster. There is no fast or easy way off Cymbalta.


Black Box Warning

ALL antidepressants and serotonin-affecting drugs come with the same black box warning (the highest level of lethal warning that can be placed on a drug).

They all also come with the same side effects, risks, dangers, and the potential for bad, long-lasting withdrawal. The best way to minimize withdrawal symptoms and reduce the risk is through a slow taper; working on diet, good nutrition, supplementing for any lacking vitamins/minerals, and other healthy, natural lifestyle changes are important for recovery.


Kindling

Kindling is caused by each withdrawal episode leading to an increase in the severity of symptoms making it more and more difficult to discontinue the drug(s).

It is a neurological condition which results from repeated withdrawal episodes from a psychiatric substance. In other words, it is a hyper-sensitization of the nervous system. It is most often associated with hypnotic drugs such as alcohol and benzodiazepines but is now being recognized with antidepressants and other psychotropic drugs. Even if a person has never had problems going on and off psychiatric drugs in the past, the next time might be the spark that ignites the inferno.


Other Support Groups

There are other peer group that advocate for slow tapering of Cymbalta/ psych drugs.

In brief: "The FDA also now warns that any abrupt change in dose of an antidepressant can produce suicide, hostility or psychosis. And these reactions can either come on very rapidly or even be delayed for months depending upon the adverse effects upon sleep patterns when the withdrawal is rapid!"

In brief: "going evenly down means going evenly down in effect at receptors. So in practice, what that means is you go down by increasingly small amounts."
"linear tapering produces hyperbolic changes, while hyperbolic tapering produces linear changes"


A good video explaining the dangers of Antidepressants on the FB group, Marriages Destroyed by Antidepressants:

CHW Dangers of Not Tapering Slowly

DISCLAIMER: THIS IS NOT MEDICAL ADVICE! We do not employ doctors or licensed medical professionals, so we do not provide medical advice. Nothing presented here is a substitute for the advice of a DOCTOR or other licensed health care provider.…

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Please take the time to report your adverse symptoms from Cymbalta and Cymbalta withdrawal to the FDA. Call 1-800-332-1088 FDA

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