DISCLAIMER: THIS IS NOT MEDICAL ADVICE! We do not employ doctors or licensed medical professionals, so we do not provide medical advice. Nothing presented here is a substitute for the advice of a DOCTOR or other licensed health care provider. Never stop, start or add medications or supplements to your health or mental health care regime without first checking for interactions or other problems, and thoroughly researching the substance. Before you employ any information here, consult your health care professional. No information here is the result of valid clinical trials.

Tapering Off Multiple Drugs

There are three schools of thought on tapering multiple drugs:

  1. Taper one drug at a time in order to see how decreases affect withdrawal symptoms.
  2. Taper all at once - very slowly -  your brain and body are already used to the combination of drugs.  So this will cause the least amount of disruption to  your brain. The problem with this method is that if one of the drugs is causing a problem, you won't know which one. Trying to figure out the different doses of all the drugs could be a challenge, too. (Antidepressant expert Ann Blake-Tracy recommends this method.)
  3. The stair-step method: one drug is slow-tapered for a while, and then tapering that drug is stopped.  Then tapering the next drug begins. By alternately tapering each drug, all drugs are slowly and deliberately discontinued.

We recommend you taper the most activating drug first

  • Normally, Cymbalta is the most activating, so you should taper that fully.  Then you taper off the ones that are more sedating.
    From Surviving Antidepressants: http://survivingantidepressants.org/topic/2207-taking-multiple-psych-drugs-which-drug-to-taper-first/
  • "If no one drug is clearly causing an adverse effect, discontinue the more activating drugs first."
  • Antidepressants and ADHD drugs (mostly amphetamine analogs) tend to be activating drugs.  These cause jitteriness, anxiety, or sleeplessness.
  • Benzodiazepines, the "Z" drugs for sleep, anticonvulsants (such as Lamotrigine), Lyrica, Gabapentin (Neurontin), and antipsychotics tend to be regulating or sedating drugs. These cause drowsiness, sluggishness or dopiness.
  • The two types of drugs can be thought of as "accelerators" and "brakes."

Many people have a sedating drug -(a brake) added to an activating drug (an accelerator) to treat drug-induced anxiety or sleep problems.

  • In this case we suggest you taper the antidepressant or stimulant first, unless you are having clear adverse reactions to a particular drug. Otherwise, you will experience activation from the other drug as you decrease the "brake." The brake may make it easier to manage withdrawal symptoms.
  • The most common and significant antidepressant withdrawal symptoms are: nervous system activations (indicating a too-fast taper); hyper-alertness; sleeplessness; abnormal anxiety; agitation etc.
  • Withdrawal sleeplessness makes tapering much harder and recovery from post-withdrawal syndrome more difficult.
  • If you reduce the accelerator while taking a sedating drug, the sedating drug may help you manage the withdrawal better. You may plan to taper the sedating drug later.

BUT ... Don't add a "brake" to prepare for withdrawal

  • Do not increase your risk of neurological damage by increasing the number of different drugs you take. A new drug may interact with one you are already taking.
  • The sedating drugs will also need tapering and can create a withdrawal syndrome of their own.
  • Remember to check drug interaction at www.drugs.com/drug_interactions.html

CHW Tapering Spreadsheets

Downloads and online calculator to help you figure out your tapering. Before you use these resources, you need to understand what you are doing, so you should read CHW Tapering Guide first.

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CHW Thyroid Issues

Here is yet another reminder that Cymbalta – whether on it or reducing – can lead to mis-diagnosis in other areas.
Cymbalta has this scary ability to “mimic” other health problems, including Thyroid issues.

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CHW Lost your insurance

If you have found yourself without insurance and can’t afford Cymbalta we have links that may help.

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CHW Other Support Organizations

DISCLAIMER: THIS IS NOT MEDICAL ADVICE! We do not employ doctors or licensed medical professionals, so we do not provide medical advice. Nothing presented here is a substitute for the advice of a DOCTOR or other licensed health care provider.…

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CHW Reinstatement Guidelines

There is only a 2 (possibly 3) week reinstatement window where it is (somewhat) safe to go back onto the drug to try to reverse the withdrawal, but only if other drugs have not been added and the person did not alternate days more than 2 (possibly 3) weeks. After that window passes, the person is left to deal with whatever comes their way. There is no known “cure” for protracted withdrawal once it settles in. It just takes time to resolve on its own.

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CHW FAQ and Key Definitions

These are simple questions, mostly with short answers. The key words will help you search the “CHW Files” list for documents giving more detail. Use the “Search” box on the CHW FB page to see what others have said about (key word) and see what they have experienced.

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Please take the time to report your adverse symptoms from Cymbalta and Cymbalta withdrawal to the FDA. Call 1-800-332-1088 FDA

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